Human centromere repositioning "in progress"
نویسندگان
چکیده
منابع مشابه
Chromosome 6 phylogeny in primates and centromere repositioning.
A panel of 15 human BAC/PAC probes, covering the entire chromosome 6, was used in FISH experiments on great apes and on representatives of Old World monkeys, New World monkeys, and lemurs to delineate the chromosome 6 phylogeny in primates. The domestic cat was used as an outgroup. The analysis showed a high marker order conservation, with few rearrangements required to reconcile the hypothesiz...
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The centromere of an eukaryotic chromosome can move to a new position during evolution, which may result in a major alteration of the chromosome morphology and karyotype. This centromere repositioning phenomenon has been extensively documented in mammalian species and was implicated to play an important role in mammalian genome evolution. Here we report a centromere repositioning event in plant...
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Accurate detection of the human metaphase chromosome centromere is a critical element of cytogenetic diagnostic techniques, including chromosome enumeration, karyotyping and radiation biodosimetry. Existing centromere detection methods tends to perform poorly in the presence of irregular boundaries, shape variations and premature sister chromatid separation. We present a centromere detection al...
متن کاملFunctional epialleles at an endogenous human centromere.
Human centromeres are defined by megabases of homogenous alpha-satellite DNA arrays that are packaged into specialized chromatin marked by the centromeric histone variant, centromeric protein A (CENP-A). Although most human chromosomes have a single higher-order repeat (HOR) array of alpha satellites, several chromosomes have more than one HOR array. Homo sapiens chromosome 17 (HSA17) has two j...
متن کاملCohesin Is Dispensable for Centromere Cohesion in Human Cells
BACKGROUND Proper regulation of the cohesion at the centromeres of human chromosomes is essential for accurate genome transmission. Exactly how cohesion is maintained and is then dissolved in anaphase is not understood. PRINCIPAL FINDINGS We have investigated the role of the cohesin complex at centromeres in human cells both by depleting cohesin subunits using RNA interference and also by exp...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2004
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.0308637101